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Mexico DF. May 6, 2015 (Informative Agency Conacyt) .- The arts have been a major part of scientific development, at least so considered Floor Gabriela Caraveo, who recently discovered what could be the cure for Parkinson’s.She noted that she could not have made the exhausted párkinson research that made had it not been for the arts, especially African dance as therapy against stress.img parkinson”I no drums could not live. While science enriches my intellectual part, no doubt including music and dance, they make me feel alive, are part of my therapy. I do not know if it’s because science stimulates part of the brain, but I feel I need to stimulate the other hand, I need to shake your hips to rest my brain from many scientific questions, “he said. In an interview with the News Agency Conacyt, scientific he revealed how was your approach to science, what attracted you to her and how she came to his recent discovery.The challenge and creativity of scienceFrom small I felt a special curiosity for all living beings around her. In eighth grade, when he studied the subject of biology, knew he wanted to study something related to medicine because he was fascinated by the subject of life.And later in high school it further became interested in science. “I was passionate about how it worked the human body, however, I realized that medicine could not deepen and answer why spend certain diseases, among other things, because the medicine is focused on treating patients affected by diseases and not so much to investigate the causes of the same, “he recalled.Therefore, he decided to study biology, “scientists are doing basic research that after doctors applied in the clinic,” he said.What we liked best about science and still remains enraptured is that it is a very creative discipline. “People think that science has nothing to do with the arts, but science itself is a very creative process, every day there is a different challenge, one question arises and to try to answer it is necessary to devise ways to you reach your answer, “he said.He added that “no day is the same, every day is a new challenge and satisfy a curiosity, science is like playing detective trying to understand how and why what happens happens.”A look inside the brainAlthough initially Dr. Immunology was not interested in neurological aspects, he discovered that the brain is a machine perfect and fascinating study.”I studied biology at the National Autonomous University of Mexico (UNAM); later, with the help of the National Council of Science and Technology (CONACYT) I won a Fulbright scholarship to study immunology, was particularly interested in this subject because my social service and thesis did with Dr. Carmen Soler at the Institute of Diagnosis and Epidemiological Reference (Indre), there studied the human immunodeficiency virus (HIV) “, he said. img1img2Flat Caraveo went to study for his doctorate at Johns Hopkins University in the United States, because that was his laboratory researcher Robert Siliciano, whose research is focused on HIV.”I got the doctorate with the idea of studying more HIV, however, after they began to interest me things very basic cell biology that ultimately were closely related to the neurosciences. So at the end I decided doctorate will make a postdoc in basic neuroscience research, “he said.Found laboratory Susan Lindquist, at the Whitehead Institute for Biomedical-Massachusetts Institute of Technology Research (MIT), in which the mechanisms by which proteins acquire their dimensional characteristics and neurological diseases associated with problems in this process are studied.”There neurological diseases called synucleinopathies, such as Parkinson’s, characterized by the aggregation of alpha-synuclein protein, which increases levels of intracellular calcium and Overactive the enzyme calcineurin, which in turn affects the function of other proteins by activating a toxic program that leads to cell death, “he explained.In the laboratory of Dr. Lindquist as unicellular yeast models to try to understand these diseases were used.Yeasts, a neural modelAlthough at first it seemed crazy to use yeast as a model to understand the functioning of a neuron, for the respondent was quite helpful: “We have been criticized for comparing a neuron with a yeast, however, evolutionarily speaking most cellular processes that make a cell function are highly conserved from yeast to neurons. Yeasts are unicellular organisms that helped us to understand the biology of multicellular organisms. “Obviously, Caraveo said floor, the degree of complexity of neurons is larger, “but if one fails to understand at the cellular level what happens, this serves as a basis to validate it in more complex systems such as mammalian brains.”He added that “everything that I found would not have found if you had used neurons from the beginning, because they are very complicated, plus they have several technical limitations system.”New uses a known drugSince he understood how these unicellular organisms function, the researcher tested in yeast and neurons of rats the drug Tacrolimus (or FK506) to reduce the toxicity associated with the aggregation of alpha-synuclein protein, which triggers the párkinson.This drug, which is currently used in transplant patients to prevent organ rejection by the immune system, cross the brain-blood barrier and is able to reduce the activation of calcineurin in the brain, which can reduce some aspects of the pathology associated with the disease.Since it is a drug approved by the Food and Drug Administration US (FDA, for its acronym in English) and the dose proposed Caraveo floor is well below the known to be immunosuppressive doses, use of this drug to address the párkinson could be used in the coming years.gab Caraveo”There are many scientists interested in bringing this to the clinic. In fact, in Boston it is organizing a series of conferences with neurologists, pharmacologists and scientists to analyze whether the results that we can bring to clinical use Tacrolimus against párkinson relatively soon, “he said.This, he said, would be his greatest achievement: “The dream of any biologist focused on biomedicine is that we do have an immediate impact on humanity.”He reiterated that after this investigation that concluded a few months ago with the publication of the article “Calcineurin Determines toxic versus beneficial responses to a-synuclein” in the journal Proceedings of the National Academy of Sciences of the United States of America, will perform other related studies The calcium.”Following this there have been many other questions also related to calcium and neurological issues that I would like to deepen” he said.He stressed that although his research has performed it in the United States, is interested whether to return or cooperate in any way with Mexico: “I want to establish my own research and would love to give back in some way to my country.”Young people, the pillar of cienciaparkinsonRegarding the role young people play, Gabriela Caraveo Floor he stressed that are essential for scientific development, it will print creativity and impetus to Orthodox-times -a research schemes.”As one matures, scientifically it accumulates more knowledge and that helps to make better performances and better sense of direction; however, the wonder of someone young is that although these clusters have no information, has a new look that often leads to fascinating places and little expected, “he said.”Over the years one goes by more rigid, but someone younger comes with a whole new perspective and perhaps with an approach that one would never have imagined. This is what makes science so rich, studying some of the less conventional way is what makes discover things that ever anyone could have imagined, “he said.